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  • Hox genes in development and beyond - PMC
    Here, we provide an overview of Hox genes, highlighting their evolutionary history, their unique genomic organization and how this impacts the regulation of their expression, what is known about their protein structure, and their deployment in development and beyond
  • Hox function and specificity – A tissue centric view
    This so-called Hox paradox is the major challenge to understand how Hox proteins play such diverse and specific roles in development Consequently, much of the work in the Hox field is focused on identifying the molecular mechanisms used by Hox TFs to regulate precise gene expression
  • Hox gene - Wikipedia
    Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body
  • HOX gene expression in the developing human spine - Nature
    Here they examine HOX gene expression in human embryos and show that neural-crest derivatives retain the anatomical HOX code of their origin while also adopting the code of their destination
  • Transcriptional Regulation and Implications for Controlling Hox Gene . . .
    In this review, we summarize some of the recent findings, ideas and emerging mechanisms underlying the regulation of transcription in general and consider how they may be relevant to understanding the transcriptional regulation of Hox genes
  • Hox genes in development and beyond - The Company of Biologists
    Here, we provide an overview of Hox genes, highlighting their evolutionary history, their unique genomic organization and how this impacts the regulation of their expression, what is known about their protein structure, and their deployment in development and beyond
  • The HOX Gene Family’s Role as Prognostic and Diagnostic . . . - MDPI
    Homeobox genes, genes that are key players during embryonic development, have been shown to have dysregulated expression patterns in multiple cancer types Therefore, this review covers the dysregulation of HOX genes and their encoded factors and the HOX family’s role as potential cancer biomarkers
  • Hox and ParaHox Genes in Evolution, Development and Genomics
    Despite the intensive research on Hox genes over the last few decades, much about the biology of these genes remains mysterious Focusing investigations on powerful genetic model species, such as fruit flies and mice, have contributed much to our understanding
  • The Generic Facet of Hox Protein Function: Trends in Genetics
    Hox proteins are master regulatory transcription factors controlling differential morphogenesis in development and evolution In doing so, each Hox protein displays unique and specific regulatory activities





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