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  • Crystalloid fluid therapy | Critical Care | Full Text
    Based on the published evidence prior to 2014, the National Institute for Health and Care Excellence (NICE) guidelines on intravenous fluid therapy in adults in hospital currently recommend the use of crystalloids that contain sodium in the range 130–154 mmol l for fluid resuscitation [25]
  • Albumin versus crystalloid solutions in patients with the acute . . .
    Discussion In the present systematic review and meta-analysis, we identified three studies that compared albumin with crystalloid solutions for intravascular volume expansion in patients with ARDS Meta-analyzing those data, we found that albumin improved oxygenation compared to crystalloids during early treatment, without affecting mortality
  • Are crystalloid-based fluid expansion strategies still relevant in the . . .
    Background Crystalloid-based fluid resuscitation has long been a cornerstone in the initial management of trauma-induced hemorrhagic shock However, its benefit is increasingly questioned as it is suspected to increase bleeding and worsen coagulopathy The emergence of alternative strategies like permissive hypotension and vasopressor use lead to a shift in early trauma care practices
  • Low-volume resuscitation with normal saline is associated with . . .
    Background Aggressively replacing severe blood loss with unbalanced crystalloids can result in hemodilution, changes in oxygen delivery, iatrogenic acidosis, and coagulopathy [1, 2] Recently, the concept of damage control resuscitation has emphasized decreased excessive crystalloid volumes and judicious administration of blood products [3]
  • Why physiology will continue to guide the choice between balanced . . .
    Background Crystalloids are the most frequently prescribed drugs in intensive care medicine and emergency medicine Thus, even small differences in outcome may have major implications, and therefore, the choice between balanced crystalloids versus normal saline continues to be debated We examined to what extent the currently accrued information size from completed and ongoing trials on the
  • Crystalloid or colloid for resuscitation. Are we any the wiser?
    Crystalloid versus colloid in fluid resuscitation [1] A total of 26 trials were selected comparing a variety of colloids carried in a variety of crystalloid solvents and compared to a variety of crystalloids, including 3 5% gelatine in the crystalloid group in one study [4] Of these studies, mortality data were presented for 19 including 1315 patients There was a claimed excess mortality of
  • Crystalloids versus colloids for goal-directed fluid therapy in major . . .
    Introduction Perioperative hypovolemia arises frequently and contributes to intestinal hypoperfusion and subsequent postoperative complications Goal-directed fluid therapy might reduce these complications The aim of this study was to compare the effects of goal-directed administration of crystalloids and colloids on the distribution of systemic, hepatosplanchnic, and microcirculatory (small
  • Crystalloids vs. colloids: KO at the twelfth round? - Critical Care
    The colloid-crystalloid debate has lingered for decades, resulting in the overall conclusion that composition of fluids for resuscitation does not influence morbidity or mortality in the general intensive care unit (ICU) population and that the only difference involves cost [1] Even with the advent of 'safer' hydroxyethyl starches (HESs) [2, 3], a mortality benefit remains elusive However
  • Resuscitation fluid types in sepsis, surgical, and trauma patients: a . . .
    Background Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects Clinical trial findings for such fluid types in different patients’ conditions are conflicting Whether the mortality benefit of balanced crystalloid than saline can be inferred from sepsis to other patient group is uncertain, and adverse effect
  • A balanced view of balanced solutions | Critical Care | Full Text
    The present review of fluid therapy studies using balanced solutions versus isotonic saline fluids (both crystalloids and colloids) aims to address recent controversy in this topic The change to the acid-base equilibrium based on fluid selection is described Key terms such as dilutional-hyperchloraemic acidosis (correctly used instead of dilutional acidosis or hyperchloraemic metabolic





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