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  • Pathology Outlines - ASCUS (cytology)
    Atypical squamous cells of undetermined significance (ASCUS) refers to cellular changes that are suggestive, but not diagnostic of, low grade squamous intraepithelial lesion (LSIL)
  • Pathology Outlines - ASC-H (cytology)
    Atypical squamous cells - cannot exclude high grade squamous intraepithelial lesion (ASC-H) refers to cytologic changes that are suggestive of high grade squamous intraepithelial lesion (HSIL) but insufficient for a definitive interpretation
  • Pathology Outlines - LSIL (cytology)
    Which of the following is the correct interpretation of the cervical cytology shown above from a 32 year old woman? Atypical glandular cells, NOS Atypical squamous cells of undetermined significance (ASCUS) Benign reactive squamous cells High grade squamous intraepithelial lesion (HSIL) Low grade squamous intraepithelial lesion (LSIL)
  • Pathology Outlines - Bethesda system
    ASCUS nuclei are enlarged by 2 to 3 times, have smooth to slightly irregular nuclear membranes, finely granular chromatin, inconspicuous nucleoli and questionable cytoplasmic cavitations
  • Pathology Outlines - Atrophy
    May cause increased incidence of ASCUS in Pap smears of peri- and post-menopausal women (Cancer 2001;93:100) Associated with scanty smears (Cytopathology 1997;8:274), ASCUS in postmenopausal women (Diagn Cytopathol 2001;24:132)
  • Pathology Outlines - HSIL CIN II CIN III
    Precancerous squamous proliferative lesion with full thickness nuclear atypia and varying degrees of cytoplasmic maturation; driven by high risk HPV subtypes
  • Pathology Outlines - Squamous dysplasia
    Squamous dysplasia is noninvasive neoplastic proliferation of the anal squamous epithelium with cytologic and architectural abnormalities; it is associated with human papillomavirus (HPV) infection
  • Pathology Outlines - HSIL (cytology)
    Cervix - HSIL cytology: changes in squamous cells associated with HPV, encompassing clinically actionable lesions previously referred to as moderate dysplasia, severe dysplasia, cervical intraepithelial neoplasia 2, CIN 3 and carcinoma in situ
  • Pathology Outlines - HPV overview
    Cotesting with cervical cytology Reflex testing for ASCUS and in postmenopausal women, for low grade SIL Genotyping for HPV 16, 18 or 45 Follow up for abnormal cervical cytology and HPV screening with negative colposcopy Follow up after treatment for cervical precancer Cervical cancer screening guideline (J Low Genit Tract Dis 2020;24:102):
  • Pathology Outlines - Cervix
    Comprehensive resource on cervical pathology including chronic cervicitis, HPV-associated squamous cell carcinoma, adenoid basal carcinoma, and related diagnostic insights





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