unfeeling 音标拼音: [ənf'ilɪŋ]
a . 无感情的,无情的,冷酷的
无感情的,无情的,冷酷的
unfeeling adj 1 :
devoid of feeling for others ; "
an unfeeling wretch " [
synonym :
{
hardhearted }, {
stonyhearted }, {
unfeeling }]
2 :
devoid of feeling or sensation ; "
unfeeling trees "
Unfeeling \
Un *
feel "
ing \,
a .
1 .
Destitute of feeling ;
void of sensibility ;
insensible ;
insensate .
[
1913 Webster ]
2 .
Without kind feelings ;
cruel ;
hard -
hearted .
[
1913 Webster ]
To each his sufferings :
all are men ,
Condemned alike to groan ;
The tender for another '
s pain ,
Th '
unfeeling for his own . --
Gray .
[
1913 Webster ] -- {
Un *
feel "
ing *
ly },
adv . --
{
Un *
feel "
ing *
ness },
n .
[
1913 Webster ]
167 Moby Thesaurus words for "
unfeeling ":
abiotic ,
affectless ,
analgesia ,
anesthesia ,
anesthetized ,
arctic ,
asleep ,
autistic ,
azoic ,
benumbed ,
blunt ,
bowelless ,
brutal ,
callosity ,
callous ,
calloused ,
callousness ,
cantankerous ,
catatonic ,
chill ,
chilly ,
churlish ,
cold ,
cold as charity ,
cold of heart ,
cold -
blooded ,
coldblooded ,
coldbloodedness ,
coldhearted ,
coldheartedness ,
coldness ,
cool ,
crotchety ,
cruel ,
dead ,
deadened ,
deadness ,
dispassionate ,
dog -
eat -
dog ,
drugged ,
dull ,
dullness ,
dumb ,
electronarcosis ,
emotionally dead ,
emotionless ,
exacting ,
exanimate ,
flinthearted ,
flinty ,
frigid ,
frosted ,
frosty ,
frozen ,
hard ,
hard of heart ,
hard -
boiled ,
hardened ,
hardhearted ,
hardheartedness ,
hardness ,
hardness of heart ,
harsh ,
heart of stone ,
heartless ,
heartlessness ,
icy ,
immovable ,
impassibility ,
impassible ,
impassive ,
imperception ,
imperceptive ,
imperceptiveness ,
imperceptivity ,
impercipience ,
impercipient ,
inanimate ,
inanimated ,
inclement ,
inconsiderateness ,
indurated ,
inert ,
inexcitable ,
inexorable ,
insensate ,
insensibility ,
insensible ,
insensibleness ,
insensitive ,
insensitiveness ,
insensitivity ,
insentience ,
insentient ,
insusceptible ,
ironhearted ,
lifeless ,
marblehearted ,
merciless ,
mute ,
narcosis ,
narcotization ,
nonconscious ,
nonemotional ,
nonliving ,
numb ,
numbed ,
numbness ,
obduracy ,
obdurate ,
objective ,
obtuse ,
obtuseness ,
out of touch ,
passionless ,
pins and needles ,
pitiless ,
pitilessness ,
relentless ,
remorseless ,
ruthless ,
self -
absorbed ,
senseless ,
severe ,
soulless ,
spiritless ,
stony ,
stonyhearted ,
surly ,
thick skin ,
thick -
skinned ,
thick -
witted ,
tough ,
unaffectionate ,
unamiable ,
unanimated ,
uncompassionate ,
uncompassioned ,
unconscious ,
uncordial ,
unemotional ,
unfeelingness ,
unfelt ,
unforgiving ,
unimpassioned ,
unimpressionable ,
unkind ,
unloving ,
unmerciful ,
unmercifulness ,
unnatural ,
unnaturalness ,
unpassionate ,
unperceptive ,
unperceptiveness ,
unpitiful ,
unpitying ,
unremorseful ,
unresponding ,
unresponsive ,
unresponsiveness ,
unsusceptible ,
unsympathetic ,
unsympathizing ,
untouchable ,
unyielding ,
without mercy
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Venetoclax, ABT-199_百度百科 ABT-199 [1](Venetoclax [2])与普通癌症药物不同,是一新型药物,通过攻击一种被称作为BCL-2的重要蛋白起到治疗癌症的作用。 BCL-2是最早发现的细胞死亡调节 BCL-2 蛋白家族的成员之一。 它与许多的癌症类型,以及一些精神疾病和自身免疫性疾病相关。
Venetoclax (ABT-199,维奈妥拉) - 仅供科研 | BCL-2抑制剂 . . . Venetoclax (ABT-199; GDC-0199) 是一种高效,有选择性和口服有效的 Bcl-2 抑制剂, K 小于0 01 nM。 Venetoclax 可以诱导自噬 (autophagy) 作用。
全球首款Bcl-2选择性抑制剂维奈克拉(ABT-199)的药物设计 Bcl-2选择性抑制剂ABT-199的分子设计思路总结。 从上述的回顾可以发现靶向PPI的分子设计是相当不容易的,维奈克拉的设计思路也是突破了传统的”rule of five”的限制,大胆创新;维奈克拉的靶点从Bcl-xL到Bcl-Xl Bcl-2再到Bcl-2,也说明first-in-class的创新要依托
Venetoclax (ABT-199),一种高效、可口服的 、有选择性 . . . Venetoclax 别名:GDC-0199; GDC 0199; GDC0199; ABT 199; ABT199 中文名称:维奈妥拉 描述:Venetoclax (ABT-199; GDC-0199) 是一种高效、可口服的 、有选择性 Bcl-2 抑制剂,无细胞试验中 Ki 小于 0 01 nM,比作用于 Bcl-xL 和 Bcl-w 选择性高 4800 倍以上,对 Mcl-1 没有抑制活性。
ABT-199 (Venetoclax) | Bcl-2 抑制剂 | 现货供应 | 美国品牌 . . . 常与ABT-199 (Venetoclax)一起在实验中被使用的化合物 A-1331852 Venetoclax和A-1331852与Nilotinib联用时,可协同降低细胞活力,增强母细胞期慢性髓系白血病细胞系的凋亡。
ABT-199, a potent and selective BCL-2 inhibitor, achieves . . . - Nature Here we report the re-engineering of navitoclax to create a highly potent, orally bioavailable and BCL-2–selective inhibitor, ABT-199 This compound inhibits the growth of BCL-2–dependent tumors
Venetoclax | Proteintech | 武汉三鹰生物技术有限公司 ABT-199 was formulated for oral dosing in 60% phosal 50 propylene glycol (PG), 30% polyethylene glycol (PEG) 400 and 10% ethanol, and bendamustine and rituximab were formulated in accordance with the manufacturer's instructions
Venetoclax - Wikipedia Venetoclax, sold under the brand names Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or acute myeloid leukemia (AML) [7][8][9]
Bcl-2抑制剂|Venetoclax (ABT-199,GDC-0199)|CAS 1257044-40-8 Venetoclax又称为ABT-199、GDC-0199,强效的、选择性的抑制Bcl-2(Ki<0 01 nM),比作用于Bcl-xL和Bcl-w选择性高4800倍以上。 Venetoclax抑制Bcl-2依赖的细胞生长,并抑制体内移植瘤生长。 Venetoclax表现出抗白血病活性。 目前,Venetoclax已用于临床Phase 3研究阶段。
Venetoclax 是一种高效,有选择性和口服有效的 Bcl-2 抑制剂 . . . 将 Venetoclax (ABT-199) 加入相同培养基中,以半对数稀释度添加,浓度从 5 μM 开始。 然后将细胞在 37°C (5% CO2) 下孵育 48 小时,并使用 Cell TiterGlo 试剂 [1] 确定对增殖的影响。 MCE 尚未独立证实这些方法的准确性。 它们仅供参考。