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unfeeling    音标拼音: [ənf'ilɪŋ]
a. 无感情的,无情的,冷酷的

无感情的,无情的,冷酷的

unfeeling
adj 1: devoid of feeling for others; "an unfeeling wretch" [synonym:
{hardhearted}, {stonyhearted}, {unfeeling}]
2: devoid of feeling or sensation; "unfeeling trees"

Unfeeling \Un*feel"ing\, a.
1. Destitute of feeling; void of sensibility; insensible;
insensate.
[1913 Webster]

2. Without kind feelings; cruel; hard-hearted.
[1913 Webster]

To each his sufferings: all are men,
Condemned alike to groan;
The tender for another's pain,
Th' unfeeling for his own. --Gray.
[1913 Webster] -- {Un*feel"ing*ly}, adv. --
{Un*feel"ing*ness}, n.
[1913 Webster]

167 Moby Thesaurus words for "unfeeling":
abiotic, affectless, analgesia, anesthesia, anesthetized, arctic,
asleep, autistic, azoic, benumbed, blunt, bowelless, brutal,
callosity, callous, calloused, callousness, cantankerous,
catatonic, chill, chilly, churlish, cold, cold as charity,
cold of heart, cold-blooded, coldblooded, coldbloodedness,
coldhearted, coldheartedness, coldness, cool, crotchety, cruel,
dead, deadened, deadness, dispassionate, dog-eat-dog, drugged,
dull, dullness, dumb, electronarcosis, emotionally dead,
emotionless, exacting, exanimate, flinthearted, flinty, frigid,
frosted, frosty, frozen, hard, hard of heart, hard-boiled,
hardened, hardhearted, hardheartedness, hardness,
hardness of heart, harsh, heart of stone, heartless, heartlessness,
icy, immovable, impassibility, impassible, impassive, imperception,
imperceptive, imperceptiveness, imperceptivity, impercipience,
impercipient, inanimate, inanimated, inclement, inconsiderateness,
indurated, inert, inexcitable, inexorable, insensate,
insensibility, insensible, insensibleness, insensitive,
insensitiveness, insensitivity, insentience, insentient,
insusceptible, ironhearted, lifeless, marblehearted, merciless,
mute, narcosis, narcotization, nonconscious, nonemotional,
nonliving, numb, numbed, numbness, obduracy, obdurate, objective,
obtuse, obtuseness, out of touch, passionless, pins and needles,
pitiless, pitilessness, relentless, remorseless, ruthless,
self-absorbed, senseless, severe, soulless, spiritless, stony,
stonyhearted, surly, thick skin, thick-skinned, thick-witted,
tough, unaffectionate, unamiable, unanimated, uncompassionate,
uncompassioned, unconscious, uncordial, unemotional, unfeelingness,
unfelt, unforgiving, unimpassioned, unimpressionable, unkind,
unloving, unmerciful, unmercifulness, unnatural, unnaturalness,
unpassionate, unperceptive, unperceptiveness, unpitiful, unpitying,
unremorseful, unresponding, unresponsive, unresponsiveness,
unsusceptible, unsympathetic, unsympathizing, untouchable,
unyielding, without mercy


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  • Venetoclax, ABT-199_百度百科
    ABT-199 [1](Venetoclax [2])与普通癌症药物不同,是一新型药物,通过攻击一种被称作为BCL-2的重要蛋白起到治疗癌症的作用。 BCL-2是最早发现的细胞死亡调节 BCL-2 蛋白家族的成员之一。 它与许多的癌症类型,以及一些精神疾病和自身免疫性疾病相关。
  • Venetoclax (ABT-199,维奈妥拉) - 仅供科研 | BCL-2抑制剂 . . .
    Venetoclax (ABT-199; GDC-0199) 是一种高效,有选择性和口服有效的 Bcl-2 抑制剂, K 小于0 01 nM。 Venetoclax 可以诱导自噬 (autophagy) 作用。
  • 全球首款Bcl-2选择性抑制剂维奈克拉(ABT-199)的药物设计
    Bcl-2选择性抑制剂ABT-199的分子设计思路总结。 从上述的回顾可以发现靶向PPI的分子设计是相当不容易的,维奈克拉的设计思路也是突破了传统的”rule of five”的限制,大胆创新;维奈克拉的靶点从Bcl-xL到Bcl-Xl Bcl-2再到Bcl-2,也说明first-in-class的创新要依托
  • Venetoclax (ABT-199),一种高效、可口服的 、有选择性 . . .
    Venetoclax 别名:GDC-0199; GDC 0199; GDC0199; ABT 199; ABT199 中文名称:维奈妥拉 描述:Venetoclax (ABT-199; GDC-0199) 是一种高效、可口服的 、有选择性 Bcl-2 抑制剂,无细胞试验中 Ki 小于 0 01 nM,比作用于 Bcl-xL 和 Bcl-w 选择性高 4800 倍以上,对 Mcl-1 没有抑制活性。
  • ABT-199 (Venetoclax) | Bcl-2 抑制剂 | 现货供应 | 美国品牌 . . .
    常与ABT-199 (Venetoclax)一起在实验中被使用的化合物 A-1331852 Venetoclax和A-1331852与Nilotinib联用时,可协同降低细胞活力,增强母细胞期慢性髓系白血病细胞系的凋亡。
  • ABT-199, a potent and selective BCL-2 inhibitor, achieves . . . - Nature
    Here we report the re-engineering of navitoclax to create a highly potent, orally bioavailable and BCL-2–selective inhibitor, ABT-199 This compound inhibits the growth of BCL-2–dependent tumors
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    ABT-199 was formulated for oral dosing in 60% phosal 50 propylene glycol (PG), 30% polyethylene glycol (PEG) 400 and 10% ethanol, and bendamustine and rituximab were formulated in accordance with the manufacturer's instructions
  • Venetoclax - Wikipedia
    Venetoclax, sold under the brand names Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or acute myeloid leukemia (AML) [7][8][9]
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    Venetoclax又称为ABT-199、GDC-0199,强效的、选择性的抑制Bcl-2(Ki<0 01 nM),比作用于Bcl-xL和Bcl-w选择性高4800倍以上。 Venetoclax抑制Bcl-2依赖的细胞生长,并抑制体内移植瘤生长。 Venetoclax表现出抗白血病活性。 目前,Venetoclax已用于临床Phase 3研究阶段。
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